Chromosome Structure and Function

Chromosome Structure and Function

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A Historical Perspective on the Study of Chromosome Structure and Function R. Appels Division of Plant Industry CSIRO P.O. Box 1600 A.C.T. AUSTRALIA qModern physical science gives us no model to explain the re duplication of the gene-string in each cell generation, or to ex plain the production of effective quantities of specific enzymes or other agents by specific genes. The precise pairing and inter change of segments by homologous gene-strings at meiosis also suggest novel physical properties of this form of matterq. Stadler (1954) The very strong influence of reductionism in the history of understanding chromosome structure and function is evident in the above quotation from Stadler's 1954 paper, qThe geneq. Earlyob servations on the constancy of the cytological appearance of chromo somes and their regular behaviour in cell division led to specula tion on their biological importance. As genetics became more refined in the early decades of the 20th century the genes-on-a string model of chromosomes developed and greater emphasis was placed on the further dissection of these structures. As a result, in the 1980's the reductionist approach is reaching a crest as extensive regions of the genetic material are being sequenced.... events) are probably maintained by some process of sister chromatid association was implied early by Darlington (1932), but this has not ... The systems studied tervention of spindle interaction under such conditions, sister chromatids tend to remain together, even though ... Diagram INTERACTIVE MEIOTIC SYSTEMS 133.

Title:Chromosome Structure and Function
Author: Rudi Appels, J. Perry Gustafson
Publisher:Springer Science & Business Media - 2012-12-06

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