MicroRNA Cancer Regulation

MicroRNA Cancer Regulation

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This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.While many questions remain to be solved, we expect the ensemble-oriented tools will prove essential to the biological interpretation of miRNA data. ... This study is partially supported by the ISF 592/07, the BSF 2007219 and the EU Framework VII of Prospects. ... Sonenberg N (2008) Mechanisms of post- transcriptional regulation by microRNAs: are the answers in sight? ... D (2005) Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.

Title:MicroRNA Cancer Regulation
Author: Ulf Schmitz, Olaf Wolkenhauer, Julio Vera
Publisher:Springer Science & Business Media - 2013-02-03

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